The Binding Factor

Research-Backed Benefits of The Binding Factor Ingredients

Immune & Cellular Support: Key Ingredients and Research-Backed Benefits

IP-6 (Inositol Hexaphosphate) – Immune & Cellular Support

• Immune Function: “Oral administration of IP6 has been reported to augment the immune response through enhanced activity of natural killer (NK) cells.”mdpi.com This suggests IP6 can bolster the body’s innate immune surveillance via increased NK cell activity.
• Antioxidant Activity: “Phytic acid (PA) has been recognized as a potent antioxidant and inhibitor of iron-catalyzed hydroxyl radical formation”pubmed.ncbi.nlm.nih.gov in both laboratory and animal studies. By chelating iron and scavenging radicals, IP6 helps protect cells from oxidative damage.

Quercetin Phytosome – Antioxidant Power & Bioavailability

• Antioxidant & Inflammatory Balance: “A growing body of evidence suggests that quercetin is a potent antioxidant and anti-inflammatory compound.”pubmed.ncbi.nlm.nih.gov Quercetin’s flavonoid activity helps neutralize free radicals and modulate inflammation, supporting overall cellular health.
• Enhanced Absorption: The phytosome delivery form (quercetin bound to phospholipids) significantly increases quercetin’s bioavailability. Research shows “significant improvements in both in vitro solubility and oral absorption…with the Quercetin Phytosome formulation as compared to unformulated quercetin,” leading to plasma quercetin levels “up to 20 times more than usually obtained” with standard formspmc.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov. In short, Quercetin Phytosome offers superior absorption for maximum benefit.

Resveratrol – Cellular & Antioxidant Defense

• Cellular Signaling: Resveratrol is known to influence cell signaling pathways related to metabolism and stress resistance. Notably, “Resveratrol has been shown to mimic effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects”nature.com, which indicates its role in healthy aging pathways (e.g. activating sirtuins/AMPK) and in reducing oxidative stress at the cellular level.
• Antioxidant Support: This plant polyphenol is widely studied for its strong antioxidant potential. In fact, “numerous studies have demonstrated that resveratrol possesses a very high antioxidant potential.”pmc.ncbi.nlm.nih.gov By scavenging free radicals and upregulating antioxidant defenses, resveratrol provides robust support against oxidative damagepmc.ncbi.nlm.nih.gov to cells.

Vitamin D (Cholecalciferol)

• Immune & Bone Health: Vitamin D “plays a role in immune function”ods.od.nih.gov and is crucial for calcium balance. It “helps your body absorb calcium, one of the main building blocks for strong bones,” and “your immune system needs vitamin D to fight off invading bacteria and viruses.”ods.od.nih.gov Adequate vitamin D supports normal immune responses and maintains healthy bones.
• Essential Nutrient: Vitamin D is well-documented as a nutrient essential for daily health. As an NIH fact sheet summarizes, “Vitamin D is a nutrient you need for good health.”ods.od.nih.gov Sufficient vitamin D status is important for numerous bodily functions including muscle function and nerve signaling, underscoring its overall health importance.

Vitamin E (d-Alpha Tocopherol Succinate)

• Antioxidant Protection: Vitamin E is a powerful fat-soluble antioxidant. According to the Office of Dietary Supplements, “antioxidant nutrients like vitamin E protect cell constituents from the damaging effects of free radicals”ods.od.nih.gov. By donating electrons, vitamin E neutralizes free radicals and prevents oxidative stress in the body.
• Cell Membrane Defense: Alpha-tocopherol (the most active form of vitamin E) is “primarily responsible for protecting cell membranes against lipid destruction caused by free radicals.”med.libretexts.org In protecting the polyunsaturated fats in cell membranes from peroxidation, vitamin E helps maintain the integrity and stability of cells under oxidative challenge.

Vitamin B12 (Methylcobalamin)

• Blood & Nerve Health: Vitamin B12 is essential for normal blood and neurological function. “Vitamin B12 is required for the development, myelination, and function of the central nervous system; [and] healthy red blood cell formation.”ods.od.nih.gov Adequate B12 supports the production of red blood cells (preventing anemia) and maintains nerve cell health and DNA synthesis.
• Active Form (Methylcobalamin): Our formula uses methylcobalamin, the coenzyme form of B12, for better utilization. “Methylcobalamin… [is one of] the metabolically active forms of vitamin B12.”ods.od.nih.gov Unlike synthetic cyanocobalamin, methylcobalamin does not require conversion to be used by the body. Research indicates this active form may be retained and used more efficiently — one study found higher tissue storage and lower urinary excretion with methylcobalamin vs. cyanocobalamin, suggesting greater bioavailabilitypmc.ncbi.nlm.nih.gov.

Selenium (L-Selenomethionine)

• Antioxidant Enzymes: Selenium is a trace mineral that supports the body’s antioxidant defense system. In fact, “selenium is a trace mineral that plays a role in antioxidant defenses as a component of glutathione peroxidase.”pubmed.ncbi.nlm.nih.gov Glutathione peroxidase (a selenium-dependent enzyme) helps neutralize peroxide free radicals, protecting cells from oxidative damage.
• Thyroid & Immune Function: Selenium also plays a role in normal thyroid hormone metabolism and immune function. According to the NIH, “Your thyroid gland needs selenium to produce hormones and function properly. Selenium is also needed… to help protect cells, and to resist infection.”ods.od.nih.gov In other words, adequate selenium supports healthy thyroid activity and a robust immune response, in addition to its antioxidant role.